Muller’s ratchet with compensatory mutations
نویسندگان
چکیده
منابع مشابه
Muller's ratchet with compensatory mutations
We consider an infinite-dimensional system of stochastic differential equations describing the evolution of type frequencies in a large population. The type of an individual is the number of deleterious mutations it carries, where fitness of individuals carrying k mutations is decreased by αk for some α > 0. Along the individual lines of descent, new mutations accumulate at rate λ per generatio...
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The vast majority of mutations are deleterious, and are eliminated by purifying selection. Yet in finite asexual populations, purifying selection cannot completely prevent the accumulation of deleterious mutations due to Muller’s ratchet: once lost by stochastic drift, the most-fit class of genotypes is lost forever. If deleterious mutations are weakly selected, Muller’s ratchet turns into a mu...
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1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK 2 Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK 3 IfADo – Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany 4 Friedrich-Baur Institute, Ludwig Maximilian University, Munich, Germany ...
متن کاملAnalysis of the fitness effect of compensatory mutations.
This paper extends previous work on the Darwinian evolutionary fitness effect of the fixation of deleterious mutations by incorporating compensatory mutations, which are mutations (deleterious by themselves) that ameliorate other deleterious mutations, thus reducing the genetic load of populations. Since having compensatory mutations essentially changes the distributional shapes of deleterious ...
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ژورنال
عنوان ژورنال: The Annals of Applied Probability
سال: 2012
ISSN: 1050-5164
DOI: 10.1214/11-aap836